m-PEG3-CH2CH2COOH is anon-cleavableADC linker used in the synthesis ofantibody-drug conjugates (ADCs). m-PEG3-CH2CH2COOH is also a PEG-basedPROTAClinker that can be used in the synthesis ofPROTACs.

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

236.26

Liquid

C₁₀H₂₀O₆

67319-28-2

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