Epoxyazadiradione

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Epoxyazadiradione

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

18385-59-6

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Epoxyazadiradione 是一种从印楝 (Azadirachta indica) 果实中提纯的柠檬苦素。Epoxyazadiradione 以可逆的方式非竞争性抑制人类 (huMIF) 和疟原虫 (恶性疟原虫 (PfMIF) 和约氏疟原虫 (PyMIF)) 的互变异构酶活性 (K_i，2.11-5.23 μM)。Epoxyazadiradione 具有抗疟原虫和人类 MIF 诱导的促炎反应的潜力。

生物活性

Epoxyazadiradione is a limonoid purified from neem (Azadirachta indica) fruits. Epoxyazadiradione inhibits the tautomerase activity of MIF of both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) andPlasmodiumyoelii (PyMIF)) non-competitively in a reversible fashion (K_i, 2.11-5.23 μM). Epoxyazadiradione has the potential against proinflammatory reactions induced by MIF of both malaria parasites and human^[1].

IC₅₀& Target

Plasmodium

分子量

466.57

Formula

C₂₈H₃₄O₆

CAS 号

18385-59-6

结构分类

Terpenoids
Triterpenes

来源

Plants
other families

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.