Psicofuramine a nucleosideantibioticand has the inhibition ofxanthosine 5'-phosphate aminase. Psicofuranine also specifically inhibitsGMPsynthase, and interruptsparasitegrowth. Psicofuranine exhibits a dose-dependent inhibition ofP. falciparumgrowth^[1][2].

Psicofuranine specifically inhibits bacterial GMP synthase as demonstrated by isolation of Psicofuranine-resistant Escherichia coli mutants with mutations in the gene encoding GMP synthase and inhibition of bacterial growth. Psicofuranine exhibits a dose-dependent inhibition ofP. falciparumgrowth with anIC₅₀of 0.3 mM. The Psicofuranine inhibitory concentration is similar to that ofE. coli^[1].

297.27

Solid

C₁₁H₁₅N₅O₅

1874-54-0

Room temperature in continental US; may vary elsewhere.

DMSO : 50 mg/mL(168.20 mM;Need ultrasonic)

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