Durlobactam sodium salt(ETX2514)

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CAS NO:

1467157-21-6

包装与价格：

产品介绍

Durlobactamsodiumsalt(ETX2514)是一种广谱β-内酰胺酶(β-lactamase)抑制剂，抑制A类酶KPC-2，C类酶AmpC和D类酶OXA-24，IC50分别为4,14和190nM。可用于治疗耐药性的革兰氏阴性菌，包括Acinetobacterbaumannii。

Cas No.	1467157-21-6
Canonical SMILES	O=S(ON1[C@@H]2C=C(C)[C@@H](C(N)=O)N(C2)C1=O)(O[Na])=O
分子式	C₈H₁₀N₃NaO₆S
分子量	299.24
溶解度	Soluble in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Durlobactam sodium salt (ETX2514) is a broad-spectrum β-lactamase inhibitor with IC50s of 4, 14 and 190 nM for Class A KPC-2, Class C AmpC and Class D OXA-24, respectively. For the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii[1]. [1]. Durand-Réville TF, et al. ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii. Nat Microbiol. 2017 Jun 30;2:17104.