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1-Methylhistamine(hydrochloride)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
1-Methylhistamine(hydrochloride)图片
CAS NO:6481-48-7
包装与价格：
包装价格(元)
10mM (in 1mL Water)电议
25mg电议
50mg电议

产品介绍
1-甲基组胺（盐酸盐）是一种组胺代谢物。
Cas No.6481-48-7
别名1-甲基组胺二对甲苯磺酸盐
化学名1-methyl-H-imidazole-4-ethanamine, dihydrochloride
Canonical SMILESCN1C=NC(CCN)=C1.Cl.Cl
分子式C6H11N3•2HCl
分子量198.1
溶解度1mg/mL in ethanol, 20mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

1-Methylhistamine is a major metabolite of histamine by histamine N-methyltransferase in the pathway of histidine metabolism.[1] It has been used as a biomarker of histaminergic system activity in the brains of Alzheimer’s disease patients as well as those with hypersomnia and other neurological conditions.[2] [3]

Reference:
[1]. Lindell, S.E., and Schayer, R.W. Metabolism of injected [14C] histamine in the kidney of the dog. Br.J.Pharmacol.Chemother. 13(1), 52-53 (1958).
[2]. Motawaj, M., Peoc'h, K., Callebert, J., et al. CSF levels of the histamine metabolite tele-methylhistamine are only slightly decreased in Alzheimer’s disease. J.Alzheimers Dis. 22(3), 861-871 (2010).
[3]. Dauvilliers, Y., Delallée, N., Jaussent, I., et al. Normal cerebrospinal fluid histamine and tele-methylhistamine levels in hypersomnia conditions. Sleep 35(10), 1359-1366 (2016).