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4-hydroxy Diclofenac
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
4-hydroxy Diclofenac图片
CAS NO:64118-84-9
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
4-羟基双氯芬酸是双氯芬酸通过细胞色素 P450 2C9 (CYP2C9) 产生的口服活性代谢物。
Cas No.64118-84-9
别名4′-羟基双氯芬酸
化学名2-[(2,6-dichloro-4'-hydroxyphenyl)amino]-benzeneacetic acid
Canonical SMILESOC(=O)Cc1ccccc1Nc1c(Cl)cc(O)cc1Cl
分子式C14H11Cl2NO3
分子量312.2
溶解度30mg/mL in ethanol, or in DMSO, or in DMF
储存条件Store at -20°C, protect from light, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

4-hydroxy Diclofenac is a CYP2C9 metabolite of the NSAID diclofenac.[1] [2] [3] By inhibiting COX and subsequently suppressing PGE2 synthesis, it demonstrates anti-inflammatory and analgesic properties.[4]

Reference:
[1]. Shimamoto, J., Ieiri, I., Urae, A., et al. Lack of differences in diclofenac (a substrate for CYP2C9) pharmacokinetics in healthy volunteers with respect to the single CYP2C9*3 allele. European Journal of Clinical Pharmacology 56, 65-68 (2000).
[2]. Sawchuk, R.J., Maloney, J.A., Cartier, L.L., et al. Analysis of diclofenac and four of its metabolites in human urine by HPLC. Pharm. Res. 12(5), 756-762 (1995).
[3]. Godbillon, J., Gauron, S., and Metayer, J.P. High-performance liquid chromatographic determination of diclofenac and its monohydroxylated metabolities in biological fluids. Journal of Chromatography 27, 151-159 (1985).
[4]. Yamakazi, R., Kawai, S., Matsumoto, T., et al. Hydrolytic activity is essential for aceclofenac to inhibit cyclooxygenase in rheumatoid synovial cells. Journal of Pharmacology and Experimental Therapeutics 289(2), 676-681 (1999)