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Fluticasone
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Fluticasone图片
CAS NO:90566-53-3
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
氟替卡松
产品介绍
Fluticasone 是一种用于呼吸道研究的吸入性皮质类固醇。Fluticasone 是一种Smo激动剂，IC50为 99 nM，可激活Hedgehog信号通路并促进初生神经干细胞或前体细胞的增殖。
生物活性

Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is aSmoagonist with anIC50value of 99 nM. Fluticasone activatesHedgehogsignaling and promotes the proliferation of primary neuronal stem or precursor cells[1][2].

体外研究
(In Vitro)

Fluticasone (0-10 μM, 2 h) inhibits U2OS cells growth with an EC50value of 99 nM[2].
Fluticasone (10-1000 nM, 48 h) decreases HRV-induced mucin production and involves in modulation of SPDEF-regulated genes and extracellular ATP release[3].

体内研究
(In Vivo)

Fluticasone (1 mg/kg; intranasal dropping; 7 d) suppresses rhinovirus-induced airways inflammation in vivo but also impairs anti-viral immune responses and increases viral titres, leading to mucus hypersecretion[4].

Animal Model:C57BL/6 mice[4]
Dosage:1 mg/kg
Administration:Intranasal dropping; 1 h before infection with rhinovirus 1B; 7 days
Result:Suppressed BAL neutrophil numbers and inhibited rhinovirus-induced airway inflammation.
Clinical Trial
分子量

444.51

Formula

C22H27F3O4S

CAS 号

90566-53-3

中文名称

氟替卡松

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.