[登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > Tosufloxacin
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Tosufloxacin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Tosufloxacin图片
CAS NO:100490-36-6
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
A-61827
产品介绍
Tosufloxacin (A-61827) 是一种具有口服活性的氟喹诺酮类抗生素。Tosufloxacin 对革兰氏阳性和革兰氏阴性细菌表现出广泛的抗菌活性。
生物活性

Tosufloxacin (A-61827) is an orally active fluoroquinoloneantibiotic. Tosufloxacin shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria[1][2].

IC50& Target

Quinolone

 

体外研究
(In Vitro)

Tosufloxacin tosylate hydrate (T-3262) (0.05-3.13 μg/mL; 18 h) shows antibacterial activities againstS. aureus,Staphylococcus epidermidis,streptococci,enterococci,Bacteroides fragilis,Clostridium difficile, andClostridium perfringens[2].

Cell Viability Assay[2]

Cell Line:S. aureus,Staphylococcus epidermidis,streptococci,enterococci,Bacteroides fragilis,Clostridium difficile, andClostridium perfringens
Concentration:0.05-3.13 μg/mL
Incubation Time:18 hours
Result:Showed MIC90s (MICs for 90% of the isolates tested) ranging from 0.05 to 1.56 μg/mL forS. aureus,Staphylococcus epidermidis,streptococci, andenterococci.
Showed MIC90s of 1.56, 3.13, and 0.20 μg/mL forBacteroides fragilis,Clostridium difficile, andClostridium perfringens, respectively.
体内研究
(In Vivo)

Tosufloxacin tosylate hydrate (T-3262) (oral gavage; 0.16-13.39 mg/kg; once) treatment shows antibacterial activity againstS. aureus,E. coli, andP. aeruginosain vivo[2].

Animal Model:Male Slc:ICR mice infected withS. aureus[2]
Dosage:1.27-2.15 mg/kg
Administration:Oral gavage; 1.27-2.15 mg/kg; once
Result:Showed 50% effective dose (ED50) of 1.62 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.0125 μg/mL.
Animal Model:Male Slc:ICR mice infected withE. coli[2]
Dosage:0.16-0.30 mg/kg
Administration:Oral gavage; 0.16-0.30 mg/kg; once
Result:Showed 50% effective dose (ED50) of 0.22 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.0125 μg/mL.
Animal Model:Male Slc:ICR mice infected withP. aeruginosa[2]
Dosage:7.66-13.39 mg/kg
Administration:Oral gavage; 7.66-13.39 mg/kg; once
Result:Showed 50% effective dose (ED50) of 10.13 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.78 μg/mL.
分子量

404.34

Formula

C19H15F3N4O3

CAS 号

100490-36-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.