Temafloxacin (TMFX) hydrochloride 是一种口服有效的喹诺酮类广谱抗菌剂。Temafloxacin hydrochloride 对下呼吸道和泌尿生殖道感染具有较好的耐受性。
| 生物活性 | Temafloxacin (TMFX) hydrochloride is an orally activequinolonebroad-spectrum antibacterial agent. Temafloxacin hydrochloride is well tolerated in lower respiratory and genitourinary tract infections[1][2]. |
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体外研究
(In Vitro) | Temafloxacin hydrochloride (0-64 μg/mL; 18-24 h) shows good antibacterial activity for gram-positive/negative bacteria, with MIC ranges of<0.004-0.5, 0.5-2 and 0.06-0.25 μg/mL forE. coli,P. aeruginosa, andS. aureus, respectively[1].
Cell Viability Assay[1] | Cell Line: | E. coli(16 strains),P. aeruginosa(13 strains), andS. aureus(17 strains) | | Concentration: | 0-64 μg/mL | | Incubation Time: | 18-24 h | | Result: | InhibitedE. coli(16 strains),P. aeruginosa, andS. aureuswith MIC ranges of<0.004-0.5 (MIC 90%=0.06, =0.06), 0.5-2 (MIC 90%=1, MIC 50%=1) and 0.06-0.25 μg/mL (MIC 90%=0.125, MIC 50%=0.125). MIC 90% and 50% means MIC for 90% and 50% of the isolates (unit: μg/mL). |
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体内研究
(In Vivo) | Temafloxacin hydrochloride (6.25, 25, 100 mg/kg; p.o.; single) shows good inhibitory activity to murine pyelonephritis[1].
Temafloxacin hydrochloride (100 mg/kg; p.o. or s.c.; single) shows rapid gastrointestinal absorption, and has excellent tissue and body fluid penetration and concentration (except for central nervous system (CNS))[1].
| Animal Model: | Female CF-1 mice (20-25 g) (murine pyelonephritis model)[1]. | | Dosage: | 6.25, 25, 100 mg/kg | | Administration: | Orally; single. | | Result: | Reduced the number of viable bacteria in the kidneys of mice. |
| Animal Model: | Female CF-1 mice (20-25 g)[1]. | | Dosage: | 100 mg/kg | | Administration: | Subcutaneously or orally; single. | | Result: | 1.19Pharmacokinetic Parameters of Temafloxacin hydrochloride in Female CF-1 mice[1].
| Cmax(μg/mL) | AUC (μg/mLoh) | T1/2(h) | % Urinary recovery | | SC (100 mg/kg) | 25.2 | 86.6 | 3.4 | 25.3 | | PO (100 mg/kg) | 13.5 | 57.4 | 1.3 | 9.1 |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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