Cilastatin sodium (MK0791 sodium) is a reversible, competitiverenal dehydropeptidase Iinhibitor with anIC₅₀of 0.1 μM. Cilastatin sodium inhibits thebacterialmetallob-lactamase enzyme CphAwith anIC₅₀of 178 μM. Cilastatin sodium is an antibacterial adjunct^[1][2][3].

Cilastatin (200 μg/mL; 24 hours; RPTECs) treatment protects against Vancomycin-induced proximal tubule apoptosis and increases cell viability, without compromising the antimicrobial effect of Vancomycin^[2].

In a mouse model (female mice, strain CD-1, 20 g) of systemic infection, Imipenem plus Cilastatin can protect mice fromS. aureus,E. coli, andP. aeruginosainfection^[3].

380.43

Solid

C₁₆H₂₅N₂NaO₅S

81129-83-1

西司他丁钠

Room temperature in continental US; may vary elsewhere.

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)