Amikacin sulfate (BAY 41-6551 sulfate) is anaminoglycosideantibiotic and a semisynthetic analog of kanamycin. Amikacin sulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin sulfate is very active against mostGram-negative bacteriaincludinggentamicin- andtobramycin-resistant strains. Amikacin sulfate also inhibits the infections caused by susceptibleNocardiaandnontuberculous mycobacteria^[1][2].

Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused byNocardia asteroides,Mycobacterium avium-intracellulare, and certain species of "rapid-growing" mycobacteria (that is,M. chelonaeandM. fortuitumi)^[1].
Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD₅₀value of 453 μM^[3].

Amikacin (320 mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats in vivo^[3].

762.14

C₂₂H₄₃N₅O₁₃.9/5H₂O₄S

149022-22-0

硫酸阿米卡星；硫酸丁胺卡那霉素

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.