Nitrofurantoin 是一种有效的，具有口服活性的，广谱-内酰胺酶抗菌剂 (antimicrobial agent)。Nitrofurantoin 是一种抗生素 (antibiotic)，可用于尿路感染 (UTIs) 的研究，包括膀胱炎和肾脏感染。
| 生物活性 | Nitrofurantoin is a potent and orally active broad-spectrum beta-lactamaseantimicrobialagent. Nitrofurantoin acts as anantibioticand can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections[1]. |
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体外研究
(In Vitro) | Nitrofurantoin (0-512 mg/L; 8 h) treatment inhibits the growth ofE. coliisolates[3].
Cell Viability Assay[3] | Cell Line: | E. coliisolates: DA10708, DA13815, DA13824, DA13957, DA13992, DA10626, DA10627 | | Concentration: | 0, 32, 64, 128, 256, and 512 mg/L | | Incubation Time: | 8 hours | | Result: | Observed bactericidal effect at 32 mg/L For DA10708, DA13815 and DA13824.
Inhibited the growth of DA13957 and DA13992 completely at 128 mg/L, observed bactericidal effect at 256 mg/L.
Showed a moderate killing at >128 mg/L for DA10626 and DA10627. |
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体内研究
(In Vivo) | 1.19Nitrofurantoin pharmacokinetic effects in SD Rats[4]. | Parameters | 10 mg/kg p.o. | 2 mg/kg i.v. | | AUC0-720(μg/mL·min) | 306 | | | AUC0-120(μg/mL·min) | | 90.3 | | AUC0-∞(μg/mL·min) | 344 | 91.5 | | Cmax(μg/mL) | 1.01 | | | CL/F or CL (ml/min/kg) | 31.0 | 22.7 | | t1/2(min) | 166 | 23.6 | | Bioavailability (%) | 60.1 | | |
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| Clinical Trial | |
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| 中文名称 | 呋喃妥因；呋喃妥英；硝基呋喃妥因；硝呋妥因；呋喃坦啶；呋喃咀啶 |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Powder | -20°C | 3 years | | 4°C | 2 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
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| 溶解性数据 | In Vitro: DMSO : 100 mg/mL(419.89 mM;Need ultrasonic) 配制储备液 | 1 mM | 4.1989 mL | 20.9943 mL | 41.9886 mL | | 5 mM | 0.8398 mL | 4.1989 mL | 8.3977 mL | | 10 mM | 0.4199 mL | 2.0994 mL | 4.1989 mL |
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。 |
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