Posizolid

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Posizolid

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

252260-02-9

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

AZD2563
AZD5847

产品介绍

Posizolid (AZD2563) 是一种 oxazolidinone 抗生素，由AstraZeneca开发用于研究细菌感染。Posizolid 具有很好的抗mycobacterial活性。

生物活性

Posizolid (AZD2563), anoxazolidinoneantibiotic, is developed byAstraZenecafor the study ofbacterialinfections. Posizolid shows very goodanti-mycobacterialactivity^[1].

IC₅₀& Target

Oxazolidinone

体外研究
(In Vitro)

Posizolid is determined the activity of against 250 highly resistant pneumococci and 267 drug-susceptible isolates. Posizolid MICs for 50 and 90% of the strains tested are 1 and 2 μg/ml and 0.5 and 1 μg/ml, respectively, for the two isolate groups^[2].

体内研究
(In Vivo)

AZD5847 DSP (AZD2563 is prodrug) could not be detected in plasma 5 min after oral administration, suggesting rapid conversion of the prodrug to the parent molecule.
In PK analysis, AZD5847(5 mg/kg) shows a low clearance (4.7 ml/min/kg) and volume of distribution (0.5 liter/kg) in mice, the half-life is 1.3 h^[3].

Animal Model:	Male BALB/c mice, aged 6 to 8 weeks, 30 to 40 g^[3].
Dosage:	3, 10, 30, 100, 300, 600, and 900 mg/kg
Administration:	oral; collect blood samples at 5 min, 10 min, 15 min, 30 min, 1 h, 2 h, 4 h, 6 h, and 24 h
Result:	AZD5847 DSP can’t be detected in plasma 5 min.

Animal Model:	Male BALB/c mice, aged 6 to 8 weeks, 30 to 40 g^[3].
Dosage:	250 mg/kg
Administration:	oral; collect blood and BAL fluid samples at 5 min, 15 min, 30 min, 1 h, 2 h, 4 h, 8 h, 16 h, 24 h, and 48 h
Result:	AZD5847(5 mg/kg) shows a low clearance (4.7 ml/min/kg) and volume of distribution (0.5 liter/kg) in mice, the half-life is 1.3 h.

分子量

465.40

Formula

C₂₁H₂₁F₂N₃O₇

CAS 号

252260-02-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.