| CAS NO: | 30827-99-7 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| 5g | 电议 |
| Molecular Weight (MW) | 239.69 |
|---|---|
| Formula | C8H11ClFNO2S |
| CAS No. | 30827-99-7 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 47 mg/mL (196.1 mM) |
| Water: 20 mg/mL (83.4 mM) | |
| Ethanol: 47 mg/mL (196.1 mM) | |
| Other info | Chemical Name: 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride InChi Key: WRDABNWSWOHGMS-UHFFFAOYSA-N InChi Code: InChI=1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H SMILES Code: O=S(C1=CC=C(CCN)C=C1)(F)=O.[H]Cl |
| Synonyms | AEBSF HCl; AEBSF hydrochloride; |
| In Vitro | In vitro activity: AEBSF inhibits the constitutive production of Aβ by directly inhibiting β-secretase in five different human cell lines, both neural and nonneural. AEBSF, as a serine protease inhibitor, inhibits the lysis of leukemic cells by human macrophages without inhibiting macrophage secretion of TNF-α and IL-1β. AEBSF also disturbs the growth of blastocysts on endometrial cells and inhibit the adhesion of HeLa cells on HUVECs by altering the protein secretion pattern Cell Assay: AEBSF was found to inhibit Aβ production in various cell lines. In K293 cells transfected with βAPP695 (K695sw), AEBSF showed dose-dependent reduction of Aβ with the IC50 value of about 1 mM. In HS695 and SKN695 cells transfected with wild-type APP695, AEBSF showed inhibition effect with IC50 value of about 300 μM. AEBSF was also found to increase α-cleavege and inhibit β- cleavage. |
|---|---|
| In Vivo | AEBSF (76.8 mg/kg daily i.p.) results in prolongation of the survival of mice that have been given a lethal T. gondii infection. AEBSF also reduces airway response and underlying inflammation in cockroach allergen-induced murine model. |
| Animal model | Mice infected by a lethal T. Gondii |
| Formulation & Dosage | Formulated in 0.89% saline; 76.8 mg/kg daily; i.p. injection |
| References | J Leukoc Biol. 1996 Sep;60(3):328-36; J Antimicrob Chemother. 2002 May;49(5):871-4; Contraception. 2011 Dec;84(6):642-8. |
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