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Quinolinic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Quinolinic acid图片
CAS NO:89-00-9
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
1g电议

产品介绍
喹啉酸是一种内源性 N-甲基-D-天冬氨酸 (NMDA) 受体激动剂,由 L-色氨酸通过犬尿氨酸途径合成,因此具有介导 N-甲基-D-天冬氨酸神经元损伤和功能障碍的潜力 .
Cas No.89-00-9
别名喹啉酸
化学名pyridine-2,3-dicarboxylic acid
Canonical SMILESOC(C1=CC=CN=C1C(O)=O)=O
分子式C7H5NO4
分子量167.12
溶解度≥ 7.8mg/mL in DMSO
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction[1][2].

Quinolinic acid (0-50 mM; 24 hours) decreases the percentage of survival cells ranging from 100±0.01% at 5 mM to 45.23±0.01% at 50 mM in N18D3 cells[2].

References:
[1]. Heyes MP, et al. Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. Brain. 1992 Oct;115 ( Pt 5):1249-73.
[2]. Jang S, et al. Neuroprotective effects of (-)-epigallocatechin-3-gallate against quinolinic acid-induced excitotoxicity via PI3K pathway and NO inhibition. Brain Res. 2010 Feb 8;1313:25-33.