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CGS 9343B
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CGS 9343B图片
CAS NO:109826-27-9
包装:10mg
市场价:3077元

产品介绍
CGS 9343B (CGS-9343B) 是一种有效的、具有口服活性和选择性的钙调蛋白抑制剂。
Cas No.109826-27-9
别名CGS-9343B; KW 5617
化学名(S)-1-(1-((4-methyl-4,6-dihydrobenzo[e]pyrrolo[2,1-c][1,4]oxazepin-4-yl)methyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one fumarate
Canonical SMILESO=C(NC1=CC=CC=C21)N2C3CCN(C[C@]4(C)OCC5=CC=CC=C5N6C4=CC=C6)CC3.OC(/C=C/C(O)=O)=O
分子式C26H28N4O2.C4H4O4
分子量544.61
溶解度<27.23mg/ml in DMSO;<5.45mg/ml in ethanol
储存条件Desiccate at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Zaldaride maleate (CGS-9343B) is a potent and selective inhibitor of calmodulin. Zaldaride maleate (CGS-9343B) inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC50 of 3.3 nM[1][2]. Zaldaride maleate (CGS-9343B) prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR[3].

References:
[1]. Norman JA, et al. CGS 9343B, a novel, potent, and selective inhibitor of calmodulin activity. Mol Pharmacol. 1987 May;31(5):535-40.
[2]. Neuhaus R, et al. Inhibition of membrane currents and rises of intracellular Ca2+ in PC12 cells by CGS 9343B, a calmodulin inhibitor. Eur J Pharmacol. 1992 Jun 5;226(2):183-5.
[3]. Li L, et al. Calmodulin regulates the transcriptional activity of estrogen receptors. Selective inhibition of calmodulin function in subcellular compartments. J Biol Chem. 2003 Jan 10;278(2):1195-200.