| CAS NO: | 136-77-6 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 2g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| 25g | 电议 |
| 50g | 电议 |
| Molecular Weight (MW) | 194.27 |
|---|---|
| Formula | C12H18O2 |
| CAS No. | 136-77-6 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 38 mg/mL (195.6 mM) |
| Water: <1 mg/mL | |
| Ethanol: 38 mg/mL (195.6 mM) | |
| Solubility (In vivo) | |
| Synonyms | 4-Hexylresorcinol |
| In Vitro | In vitro activity: Previous research showed hexylresorcinol could inhibit both mono- and di-phenolase activity of mushroom tyrosinase. Moreover, hexylresorcinol at 2 μM lengthened the lag period from 98 s to 26. Hexylresorcinol could also display reversible inhibition of the enzyme. In addition, the kinetic analyses showed that hexylresorcinol was a competitive inhibitor with the apparent inhibition constant binding with free enzyme to be 0.443 μM for diphenolase Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Iin vivo study showed that hexylresorcinol could induce chromosome aberrations in mouse eukaryotic cells at doses of 0.5, 0.05, and 0.005 mg/g and the metabolic transformation of hexylresorcinol decreased its genotoxic effect in mice. Moreover, the mutagenic effect lasted for 3 days only at the highest dose of hexylresorcinol (0.5 mg/g). Thus, hexylresorcinol doses less than 0.5 mg/g were metabolized within two days to the extent of the cytotoxic effect. In addition, hexylresorcinol was transformed at a rate of 0.0025–0.025 mg/day after a single administration to mice |
| Animal model | |
| Formulation & Dosage | |
| References | Protein J. 2004 Feb;23(2):135-41; Genetika. 2005 Aug;41(8):1045-8. |
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