Vanoxerine

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Vanoxerine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

67469-69-6

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

GBR 12909
I893

产品介绍

Vanoxerine (GBR-12909) 是竞争性的，有效选择性的多巴胺再摄取(dopamine reuptake)抑制剂。Vanoxerine (GBR-12909) 与多巴胺转运体 (DAT) 上的靶点结合。

生物活性

Vanoxerine (GBR-12909) is a competitive, potent, and highly selectivedopamine reuptakeinhibitor (K_i=1 nM). Vanoxerine (GBR-12909) binds to the target site on thedopamine transporter(DAT)^[1].

IC₅₀& Target

Ki: 1 nM (dopamine reuptake)^[1]

体外研究
(In Vitro)

Vanoxerine (GBR-12909) inhibits the uptake of dopamlne (DA), with an IC₅₀in the low nanomolar range, and is several-fold less potent as inhibitors of the uptake of noradrenaline and 5-HT^[2].
Vanoxerine (GBR-12909) is also an oral, mixed ion channel blocker with IKr, INa, and L-type calcium channel activity^[3].

体内研究
(In Vivo)

Vanoxerine (GBR-12909) (2.5-20 mg/kg; i.p.) significantly increases the ambulatory activity^[3].

Animal Model:	Male mice(ddY strain at 6 weeks of age)^[3]
Dosage:	2.5, 5, 10, 20 mg/kg
Administration:	Intraperitoneal injection
Result:	The ambulatory activity of mice increased in a dose-dependent manner, with a maximal increase at 30 min after the administration.

Clinical Trial

分子量

450.56

Formula

C₂₈H₃₂F₂N₂O

CAS 号

67469-69-6

中文名称

伐诺司林；伐洛司林

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.