Bupropion morpholinol (Hydroxy Bupropion) is a major metabolite of Bupropion. Bupropion morpholinol inhibitsDopamine,Norepinephrine transportersand theα4β2 nicotinic receptorin vitro. Bupropion morpholinol contributes to antidepressant and smoking cessation activities^[1][2][3].

Dopamine transporter^[2], Norepinephrine transporter^[2], α4β2 nicotinic receptor^[2]

Bupropion morpholinol is produced from Bupropion by the genetically polymorphic enzyme CYP2B6 in vivo^[1].
Bupropion morpholinol inhibits [³H]norepinephrine uptake with an IC₅₀of 1.7 μM^[2].

255.74

Solid

C₁₃H₁₈ClNO₂

357399-43-0

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

DMSO : 20 mg/mL(78.20 mM;Need ultrasonic and warming)

Ethanol : 20 mg/mL(78.20 mM;Need ultrasonic and warming)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。