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Allopurinol Sodium
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Allopurinol Sodium图片
CAS NO:17795-21-0
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
别嘌醇钠
产品介绍
Allopurinol sodium 是一种有效的口服活性黄嘌呤氧化酶xanthine oxidase抑制剂，IC50值为0.2-50 μM。Allopurinol sodium 可用于治疗高尿酸血症和痛风。Allopurinol sodium 降低 HIF-1α 和 HIF-2α 蛋白的表达。Allopurinol sodium 显示出抗抑郁和抗伤害活性。Allopurinol sodium 具有抗利什曼原虫作用。
生物活性

Allopurinol sodium is a potent and orally activexanthine oxidaseinhibitor with anIC50value of 0.2-50 μM. Allopurinol sodium can be used in the treatment of hyperuricemia and gout. Allopurinol sodium decreases the expression of HIF-1α and HIF-2α protein. Allopurinol sodium shows anti-depressant and anti-nociception activity. Anti-leishmanial effect[1][2][3][4][5].

体外研究
(In Vitro)

Allopurinol sodium (0, 10, 100, 1000 μg/ml; 17 h) decreases the expression of HIF-1α and HIF-2α protein in HFF and HUVEC cells[5].
Allopurinol sodium (0, 10, 100, 1000 μg/ml; 24 h) reduces angiogenesis traits of HUVEC cells[5].

Western Blot Analysis[5]

Cell Line:HFF, HUVEC cells
Concentration:0, 10, 100, 1000 μg/ml
Incubation Time:17 h
Result:Reduced HIF-1α and HIF-2α protein expression in a dose dependent manner.
体内研究
(In Vivo)

Allopurinol sodium (39 mg/kg; p.o.; daily for 21 successive days) shows anti-depressant activity in mouse[3].
Allopurinol sodium (10-400 mg/kg; i.p.) induces anti-nociception activity in mouse[4].

Animal Model:20-30 g, male Swiss Albino mice[3]
Dosage:39 mg/kg
Administration:P.o.; daily for 21 successive days
Result:Reduced the immobility time in the FST with the immobility time of 129.8±10.5 s.
Animal Model:30-40 g, male adult Swiss albino mice[4]
Dosage:10, 50, 100, 200, 400 mg/kg
Administration:I.p.
Result:Produced dose-dependent anti-nociception in the tail-flick, hot-plate.
Clinical Trial
分子量

160.11

Formula

C5H5N4NaO

CAS 号

17795-21-0

中文名称

别嘌醇钠

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.