Fuzapladib (IS-741) is a potentphospholipaseA2 inhibitor. Fuzapladib can block the adhesion of inflammatory cells to microvascular endothelial cells, inhibit the infiltration of neutrophils into the pancreas or acute pancreatitis, and has anti-acute pancreatitis effects^[1].

Fuzapladib(IS-741)(1 μM, 3 h)在脂多糖刺激下，可显着抑制 HL-60 细胞与 HUVEC 的粘附^[1]。

Fuzapladib(IS-741)(p.o., 50 mg/kg, 7 days) 显着降低了大鼠回肠中的髓过氧化物酶 (MPO) 活性和粘膜 IL-8 水平，减少了多形核细胞和 Mac-1 阳性细胞向发炎病灶的浸润，有效减轻了三硝基苯磺酸(TNBS)诱导的大鼠回肠炎^[2]。

379.40

C₁₅H₂₀F₃N₃O₃S

141283-87-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.