SCH-42354 is a potent, orally activeneutral endopeptidase (NEP)inhibitor, is the pharmacologically active form of the prodrug SCH-42495. SCH-42354 inhibits the hydrolysis of NEP to enhance the activity of atrial natriuretic peptide (ANP). SCH-42354 inhibits hydrolysis of leu-enkephalin and ANF withIC₅₀values of 8.3 nM and 10.0 nM, respectively. SCH-42354 has antihypertensive activity^[1][2].

SCH-42354 (10-100 nM) increases the potency of natriuretic peptide (ANP) in isolated pulmonary vessels and in isolated perfused whole lungs and increases ANP activity in a dose-dependent manner^[1].

341.49

C₁₆H₂₃NO₃S₂

144505-58-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.