TD-0212 (compound 35) is an orally active dual pharmacologyangiotensin II type 1 receptor (AT₁)antagonist andneprilysin(NEP)inhibitor, with apK_iof 8.9 for AT₁and apIC₅₀of 9.2 for NEP^[1].

pKi: 8.9 (AT₁)
pIC50: 9.2 (NEP)^[1].

TD-0212 (compound 35) provides the enhanced activity of dual AT1/NEP inhibition with a potentially lower risk of angioedema relative to dual ACE/NEP inhibition^[1].

TD-0212 (compound 35) produces blood pressure reductions similar to omapatrilat and combinations of AT1 receptor antagonists and NEP inhibitors in models of renin-dependent and –independent hypertension^[1].

527.65

C₂₈H₃₄FN₃O₄S

1073549-10-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.