GSK3987 is a panLXRα/βagonist withEC₅₀s of 50 nM, 40 nM for LXRα-SRC1 and LXRβ-SRC1, respectively. GSK3987 increases the expression of ABCA1 and SREBP-1c. GSK3987 induces cellularcholesterolefflux and triglyceride accumulation^[1].

EC₅₀: 50 nM (LXRα); 40 nM (LXRβ)^[1]

GSK3987 (compound 4) shows activity with EC₅₀s of 0.08 μM, 50 nM, 40 nM for ABCA1, LXRα-SRC1, LXRβ-SRC1, respectively^[1].
GSK3987 (30, 100, 300, 1000 nM) increases the expression of ABCA1 and induces cellular cholesterol efflux to apoA1 particles in a dose-dependent manner in primary human macrophages^[1].
GSK3987 (6-1500 nM) increases the expression of SREBP-1c and induces triglyceride accumulation in human hepatoma (HepG2) cells in a dose-dependent manner^[1].

384.43

Solid

C₂₄H₂₀N₂O₃

264206-85-1

Room temperature in continental US; may vary elsewhere.

DMSO : 100 mg/mL(260.13 mM;Need ultrasonic)

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