M1002 是一种缺氧诱导因子-2 (HIF-2) 激动剂，可以增强 HIF-2 靶基因的表达。M1002 与脯氨酰羟化酶结构域 (PHD) 抑制剂可发挥协同作用。
| 生物活性 | M1002 is ahypoxia-inducible factor-2(HIF-2) agonist, and can enhance the expression of HIF-2 target genes. M1002 shows synergy with prolyl-hydroxylase domain (PHD) inhibitors[1]. |
体外研究
(In Vitro) | M1002 (10 μM; 24 h) enhances the expression of HIF-2 target genes with great efficacy[1].
M1002 (5 μM; 24 h) treatment shows synergy with prolyl hydroxylase domain (PHD) inhibitors[1].
RT-PCR[1] | Cell Line: | 786-O cells | | Concentration: | 10 μM | | Incubation Time: | 24 hours | | Result: | Showed clear agonistic effects on the expression of HIF-2 target genes in 786-O cells as compared with the control. |
RT-PCR[1] | Cell Line: | Hep3B cells | | Concentration: | 5 μM | | Incubation Time: | 24 hours | | Result: | Elevated the expression of EPO and NDRG1 by co-treatment of M1002 together with PHD inhibitors, compared with M1002 alone treatment. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Powder | -20°C | 3 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
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