BCP-T.A, a tunable heterocyclic electrophile, is a potentferroptosisinducer by binding toGPX4^[1].

GPX4^[1]

BCP-T.A induces ferroptosis in various cell lines (NCI-H522, T-1080, MDA-MB-468, MDA-MB-231, HeLa, HCT-116, U2OS, WI-38, and MEFS) with IC₅₀values of 10 nM-367 nM^[1].
BCP-T.A (0.5 μM, 3 h) binds to GPX4 and increases lipid peroxides, indicated by cellular thermal shift assay (CETSA)^[1].

456.39

C₂₃H₁₉Cl₂N₃OS

2786829-70-5

Room temperature in continental US; may vary elsewhere.

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