FB23 is a potent and selectiveFTO demethylaseinhibitor with anIC₅₀of 60 nM. FB23 directly binds toFTOand selectively inhibitsFTO's mRNA N⁶-methyladenosine (m6A) demethylase activity^[1].

IC50: 60 nM (FTO)^[1]

FB23 (72 hours) treatment inhibits acute myeloid leukemia (AML) cells proliferation with IC₅₀values of 44.8 μM, 23.6 μM for NB4 and MONOMAC6 AML cells^[1].
FB23 treatment causes the significant suppression of MYC targets, E2F targets, and G2M checkpoint signal cascades, which may contribute to the inhibitory effects of FTO inhibitors and FTO KD on cell cycle and proliferation. FB23 treatments activates apoptosis and p53 pathways^[1].

A single dose of 3 mg/kg FB23 is i.p. administrated to Sprague Dawley (SD) rats for the pharmacokinetic profile. The C_maxand T_maxvalue of FB23 are 142.5 ng/mL and 0.4 hr, respectively^[1].

377.22

Solid

C₁₈H₁₄Cl₂N₂O₃

2243736-35-6

Room temperature in continental US; may vary elsewhere.

DMSO : 125 mg/mL(331.37 mM;Need ultrasonic)

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