Edoxaban hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

480448-29-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

DU-176 hydrochloride

产品介绍

Edoxaban (DU-176b) hydrochloride 是一种具有口服活性、高效、选择性和直接的Factor Xa (FXa)抑制剂，对人游离FXa和凝血酶原酶的K_i值分别为 0.561 nM 和 2.98 nM。Edoxaban hydrochloride 的选择性是其他凝血蛋白酶的 10000 倍以上。Edoxaban hydrochloride 可用于预防血栓栓塞性疾病的研究。

生物活性

Edoxaban (DU-176b) hydrochloride is an orally active, highly potent, selective, and directFactor Xa(FXa)inhibitor withK_ivalues of 0.561 and 2.98 nM for free humanFXaandprothrombinase. Edoxaban hydrochloride exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban hydrochloride can be used for preventing thromboembolic disease research^[1].

IC₅₀& Target

IC50: 2.90 μM (platelet aggregation), Ki: 0.561 nM (free human FXa), 2.98 nM (prothrombinase), 0.715 nM (cynomolgus monkey FXa), 0.457 nM (rabbit FXa)^[1]

体外研究
(In Vitro)

Edoxaban hydrochloride (1, 1 and 5 minutes respectively) prolongs PT,TT and APTT of human plasma in a concentration-dependent manner^[1].
Edoxaban hydrochloride inhibits thrombin-induced platelet aggregation, with an IC₅₀of 2.90 μM^[1].

Cell Viability Assay^[1]

Cell Line:	Human, rat, cynomolgus monkey and rabbit plasma; Human platelet
Concentration:
Incubation Time:	1 and 5 minutes
Result:	Antithrombin.

体内研究
(In Vivo)

Edoxaban hydrochloride (0.5, 2.5 and 12.5 mg/kg; p.o.; once) significantly and dose-dependently reduces the thrombus formation and prolongs PT^[1].

Animal Model:	Male Slc: Wistar rats (210-240 g); Male New Zealand White rabbits(2.5-3.5 kg) (Both are venous stasis thrombosis model)^[1].
Dosage:	0.5, 2.5 and 12.5 mg/kg
Administration:	Oral administration; once
Result:	Inhibited exogenous FXa activity. Antithrombotic.

Clinical Trial

分子量

584.52

Formula

C₂₄H₃₁Cl₂N₇O₄S

CAS 号

480448-29-1

中文名称

盐酸依度沙班；盐酸伊多塞班；盐酸艾多沙班

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.