Esomeprazole ((S)-Omeprazole) is a potent and orally activeproton pumpinhibitor and reduces acid secretion through inhibition of theH⁺, K⁺-ATPasein gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research^[1][2][3].

H⁺, K⁺-ATPase^[1][2]

Esomeprazole (25-100 μM; 20 hours; MDA-MB-468 cells) treatment suppresses growth of triple-negative breast cancer cell in vitro in a dose-dependent manner through increase in their intracellular acidification^[1].

Esomeprazole (30-300 mg/kg; oral gavage; daily; for 19 or 11 days; C57BL/6J mice) treatment significantly inhibits the progression of fibrosis throughout the lungs of the animals. Esomeprazole also reduces circulating markers of inflammation and fibrosis^[2].

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C₁₇H₁₉N₃O₃S

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埃索美拉唑

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