HQL-79, a potent, selective and orally active humanhematopoietic prostaglandin D synthase (H-PGDS)inhibitor, highly selectively inhibits the synthesis of PGD₂, and acts as an anti-allergic agent, with aK_dof 0.8 μM and anIC₅₀of 6 μM. Shows no obvious effect onCOX-1,COX-2, m-PGES, or L-PGDS^[1].

IC50: 6 μM (H-PGDS)^[1]
Kd: 0.8 μM (H-PGDS)^[1]

HQL-79 is a competitive inhibitor against substrate PGH2 and a non-competitive one against GSH^[1].

377.48

Solid

C₂₂H₂₇N₅O

162641-16-9

Room temperature in continental US; may vary elsewhere.