MIF098

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MIF098

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1208448-95-6

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

MIF098 是一种巨噬细胞迁移抑制因子 (MIF) 拮抗剂，可抑制肺平滑肌细胞增殖、迁移和纤维化。MIF098 可用于免疫炎症相关疾病研究。

生物活性

MIF098 is amacrophage migration inhibitory factor(MIF) antagonist. MIF098 inhibits proliferation, migration and fibrosis of pulmonary smooth muscle cells. MIF098 can be used for immunoinflammation-related disease research^[1].

体外研究
(In Vitro)

MIF098 (0-10 μM, 48 h) inhibits mPASMC cell proliferation and migration in a concentration-dependent manner, by blocking the migration inhibitory factor (MIF) pathway^[1].
MIF098 reduces collagen synthesis and pulmonary artery fibrosis by inhibiting the TGFβ1/Smad2/3 pathway^[1].

Western Blot Analysis^[1]

Cell Line:	Mouse pulmonary artery smooth muscle cells (mPASMCs)
Concentration:	0-10 μM
Incubation Time:	48 hours
Result:	Reduced expression of cell cycle related proteins such as cyclin D1, CDK4 and CDK6 in PDGF-BB and increased expression of cell-cycle arrest proteins such as P53 and P21. Reduced TGFβ1-induced fibronectin (FN), collagen I (col I), and collagen II (col II) expression and phosphorylation of Smad2 and Smad3.

体内研究
(In Vivo)

MIF098 (intraperitoneal injection, 40 mg/kg, once a day, 4 weeks) attenuates the process of hypoxia-induced pulmonary arterial hypertension in C57BL/6J mice^[1].

Animal Model:	Hypoxic male C57BL/6J mice^[1]
Dosage:	40 mg/kg
Administration:	Intraperitoneal injection; once a day; 4 weeks
Result:	Reduced right ventricular systolic pressure (RVSP), percentage medial wall thickness, muscularization and right ventricle collagen deposition. Decreased percentage of collagen fibers in pulmonary artery (PA).

分子量

255.27

Formula

C₁₅H₁₃NO₃

CAS 号

1208448-95-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.