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U-46619
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
U-46619图片
CAS NO:56985-40-1
包装与价格：
包装价格(元)
1mg (28.5 mM * 100 μL in Methyl acetate)电议
5mg (28.5 mM * 500 μL in Methyl acetate)电议

产品名称
9,11-Methanoepoxy PGH2
产品介绍
U-46619 (9,11-Methanoepoxy PGH2) 是一种稳定的血栓素 A2 (TXA2) 的类似物，也是一种有效的TXA2激动剂。
生物活性

U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of thromboxane A2 (TXA2) and acts as a potentTXA2agonist[1].

IC50& Target

TXA2[1]

体外研究
(In Vitro)

U-46619 (1 nM-10 μM) causes platelets shape change and aggregation in a concentration-dependent manner, and with EC50s of 0.58 μM and 0.013 μM for aggregation and shape change, respectively[1].
U-46619 (10 nM-10 μM) increases internal Ca2+concentration ([Ca2+]i) and activates phosphoinositide (PI) hydrolysis in a concentration-dependent manner with a similar concentration-dependency[1].
U-46619 (3 nM-10 μM) also activates GTPase concentration-dependently in the membranes derived from platelets[1].
U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways[2].

体内研究
(In Vivo)

U-46619 (5 μg/kg; i.v.) increases blood pressure in male spontaneously hypertensive rats (SHR)[3].

Animal Model:12-15 weeks-old male and female SHR[2]
Dosage:5 μg/kg
Administration:Intravenous injection
Result:Induceed a significant increase of MABP after 1 min in male SHR.
分子量

350.49

性状

Liquid

Formula

C21H34O4

CAS 号

56985-40-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years