MRS2279 diammonium is a selective and high affinityP2Y1receptor antagonist, with aK_ivalue of 2.5 nM and anIC₅₀value of 51.6 nM. MRS2279 diammonium competitively inhibits ADP-promoted platelet aggregation with anpK_bvalue of 8.05^[1][2][3].

MRS2279 diammonium antagonizes 2-MeSADP-stimulated inositol phosphate formation in turkey erythrocyte membranes with a pK_bvalue of 7.75^[2].
MRS2279 diammonium shows high affinity competitive antagonism to human P2Y1 receptor with a pK_bvalue of 8.10 in 1321N1 human astrocytoma cells^[2].
MRS2279 diammonium shows specific effect for the P2Y1 receptor, but shows no effect on activation of the human P2Y2, P2Y4, P2Y6, or P2Y11 receptors by their cognate agonists^[2].
MRS2279 diammonium shows no ability to block the capacity of ADP to act through the Gi/adenylyl cyclase linked P2Y receptor of platelets to inhibit cyclic AMP accumulation^[2].

MRS2279 diammonium (2 μL, 1 nM; intracerebroventricular injection; 30 min prior to mechanical ventilation) reduces mouse brain injury induced by mechanical ventilation in high-pressure ventilation mice^[3].

503.77

Solid

C₁₃H₂₄ClN₇O₈P₂

2387505-47-5

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)