WAY-267464

立即咨询

WAY-267464

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

847375-16-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

WAY-267464 是非肽催产素受体(OTR)激动剂。WAY-267464 通过抗利尿激素 1A 受体拮抗剂作用损害大鼠的社会认知。WAY-267464 可用于精神障碍的研究，如自闭症谱系障碍、精神分裂症和社交焦虑障碍。(OTR)

生物活性

WAY-267464 is a non-peptideoxytocin receptor(OTR)agonist. WAY-267464 can impair social recognition memory in rats through a vasopressin 1A receptor antagonist action. WAY-267464 can be used for the research of psychiatric disorders, such disorders include autism spectrum disorder, schizophrenia, and social anxiety disorder^[1].

体内研究
(In Vivo)

WAY-267464 (i.p., 100 mg/kg) has antagonism of the memory-enhancing effects of AVP (0.005 mg/kg) on social recognition at a retention interval of 120 min^[1].
WAY-267464 (i.p., 10 and 30 mg/kg) has the antagonist effects on the arginine vasopressinVasopressin(HY-P0049) (AVP)-induced (0.005 mg/kg) facilitation of social recognition at a retention interval of 120 min^[1].
WAY-267464 (i.p., 30 and 100 mg/kg, given alone) impairs memory at a 30 min retention interval^[1].

Animal Model:	Male Wistar Rats (adult: 9-10 weeks; juvenile: 3-4 weeks)^[1]
Dosage:	1, 10, 30, and 100 mg/kg
Administration:	Intraperitoneal; 1, 10, 30, and 100 mg/kg
Result:	Completely prevented the AVP-induced preference for the novel over the familiar juvenile stimulus rats. Prevented the increase in preference for the novel over the familiar juvenile stimulus rat induced by AVP at 10 and 30 mg/kg, but not 1 mg/kg.

分子量

581.66

Formula

C₃₂H₃₅N₇O₄

CAS 号

847375-16-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.