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TC-MCH 7c
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
TC-MCH 7c图片
CAS NO:864756-35-4
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
TC-MCH 7c 是一种苯基吡啶酮衍生物，一种口服有效的，选择性的且可穿透血脑屏障的MCH1R拮抗剂，对 hMCH1R 的IC50为 5.6 nM。TC-MCH 7c 对人和小鼠 MCH1R 的Ki分别为 3.4 nM 和 3.0 nM。
生物活性

TC-MCH 7c, a phenylpyridone derivative, is an orally available, selective and brain-penetrableMCH1Rantagonist with anIC50of 5.6 nM for hMCH1R[1]. TC-MCH 7c hasKis of 3.4 nM and 3.0 nM of human and mouse MCH1R, respectively[2].

IC50& Target

IC50: 5.6 nM (hMCH1R)[1]
Ki: 3.4 nM (hMCH1R) and 3.0 nM (mouse MCH1R)[1]

体外研究
(In Vitro)

TC-MCH 7c has an IC50of 9.7 μM for MCH1R in [Ca2+]i mobilization[1].
TC-MCH 7c has IC50s of 23 nM and 9.0 μM for FLIPR and hERG, respectively[2].

体内研究
(In Vivo)

TC-MCH 7c (oral; 3-30 mg/kg; once-daily for 1.5 months) exhibits excellent body weight reduction in a dose-dependent manner in DIO mice model[1].
TC-MCH 7c (oral; 3-30 mg/kg) with 30 mg/kg has plasma concentrations of 5.1, 1.8, and 0.7 μM at 2, 15, and 24 hours, respectively[2].

Animal Model:C57BL/6J DIO mice[1]
Dosage:3, 10 and 30 mg/kg
Administration:Oral; once-daily for 1.5 months
Result:Exhibited excellent body weight reduction in a dose-dependent manner.
Animal Model:Diet-induced obesity mice[2]
Dosage:3, 10 and 30 mg/kg (Pharmacokinetic Analysis)
Administration:Oral
Result:Plasma concentrations at 2, 15, and 24 hours were 5.1, 1.8, and 0.7 μM, respectively.
分子量

408.47

性状

Solid

Formula

C24H25FN2O3

CAS 号

864756-35-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month