Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-basedPROTAClinker that can be used in the synthesis ofPROTACs^[1][2][3].

Leukotriene B4 induces recruitment and activation of neutrophils, monocytes and eosinophils. It also stimulates the production of a number of proinflammatory cytokines and mediators indicating an ability to augment and prolong tissue inflammation^[2].
Leukotriene B4 is a pro-inflammatory mediator synthesised in myeloid cells from arachidonic acid^[2].

336.47

Liquid

C₂₀H₃₂O₄

71160-24-2

• Ketones, Aldehydes, Acids

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years