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RHPS4
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
RHPS4图片
CAS NO:390362-78-4
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议

产品介绍
RHPS4 是有效的端粒酶 (telomerase) 抑制剂 (IC50= 0.33 μM)。RHPS4 是 DNA 损伤的诱导剂。
生物活性

RHPS4 is a potenttelomeraseinhibitor (IC50= 0.33 μM). RHPS4 is a DNA damage inducer[1][2].

IC50& Target

IC50: 0.33 μM (telomerase in the TRAP assay)[1].

体外研究
(In Vitro)

RHPS4 could sensitize tumor cells to anticancer agents that act via disparate mechanisms[1].
RHPS4 (0.5-1 μM, 15 days) induces a senescent-like growth arrest in MCF-7 cells[1].
RHPS4 (1 μM, 4 days) induces phosphorylation of H2AX in transformed and tumor cells[2].

Cell Proliferation Assay[1]

Cell Line:MCF-7, MCF-7 vector control, and MCF-7 c81 cells.
Concentration:0, 0.2, 0.5, or 1 μM.
Incubation Time:7 days.
Result:Inhibited cell proliferation.
体内研究
(In Vivo)

RHPS4 (15 mg/kg, iv, 15 days) treatment produces a marked inhibition of tumor weight (tumor weight inhibition [TWI] about 80%; P< 0.001) in a very short time, and this effect persists for at least 30 days. A complete tumor response is observed in 80% of mice, and 40% are cured[2].
In all the other tumor xenografts, RHPS4 treatment produces about 50% (P< 0.001) TWI at the nadir of the effect and, more important, results in a delay of tumor growth of about 15 (M14 and PC3) and 10 (HT29 and H460) days[2].

Animal Model:CD-1 male nude (nu/nu) mice, 6–8 weeks old and weighing 22-24 g (H460, CG5 and HT29, PC3 and M14 cancer models)[2].
Dosage:15 mg/kg.
Administration:IV, daily for 15 consecutive days.
Result:Active as a single agent on all the tumors analyzed. CG5 breast xenografts resulted in the most sensitive tumor.
分子量

458.48

性状

Solid

Formula

C23H20F2N2O4S

CAS 号

390362-78-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO : 1 mg/mL(2.18 mM;ultrasonic and warming and heat to 60℃)

H2O :< 0.1 mg/mL (ultrasonic;warming;heat to 60℃)(insoluble)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.1811 mL10.9056 mL21.8112 mL
5 mM---------
10 mM---------
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。