Gentamicin, an orally activeaminoglycosideantibiotic, inhibits the growth of both gram-positive and gram-negativebacteriaand to inhibit several strains of mycoplasma in tissue culture. Gentamicin inhibitsDNase Iwith anIC₅₀of 0.57 mM^[1][2][3][4].

Gentamicin is a more effectivein vitrobacterial inhibitor than combined penicillin-streptomycin, is nontoxic to tissue culture monolayers, and does not inhibit virus replication^[2].
Gentamicin has been used with success as an additive in commercial mycology media to inhibit growth of bacteria and has been shown to be bactericidal for a wider range of organisms (Pseudomonas aeruginosa,Proteus sp., andStreptococcus faecalis) than penicillin and streptomycin^[2].
Gentamicin does not interfere with the production of cytopathic effect by certain echoviruses and polioviruses in tissue culture, is nontoxic to Rhesus monkey kidney, HeLa, and human amnion cells, and is stable at autoclave temperatures^[2].
Gentamicin is produced by various species of the genusMicromonospora^[3].
Gentamicin C1a binds in the major groove of the A-site of the RNA^[3].

Gentamicin (oral and injectable forms) exhibits effective antibacterial activity againstYersinia pestisas demonstrated in a mouse infection model^[3].
Gentamicin (0.27 g/kg) shows a significant reduction of bacteria on the foreign body in mouse^[4].

C₂₄H₅₃N₇O₇^3*

1403-66-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.