Meropenem (SM 7338) is a carbapenemantibioticwith broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistantN. gonorrhoeae(MIC value of 0.02-0.06 mg/mL),H. influenzae(MIC value of 0.03-0.12 mg/mL), andH. ducreyi(MIC value of 0.015-0.12 mg/mL)^[1][2].

Meropenem is intrinsically stable to dehydropeptidase-1 (DHP-1) degradation and Meropenem acts by inhibiting bacterial cell wall synthesis by binding to and inactivating penicillin-binding proteins (PBPs). Meropenem possesses broad-spectrum in vitro activity, which includes activity against many Gram-positive, Gram-negative and anaerobic bacteria; Meropenem lacks activity against Enterococcus faecium, methicillin-resistant Staphylococcus aureus and Stenotrophomonas maltophilia^[2].

Meropenem (60 mg/kg; intraperitoneal injection; once; SD rats) treatment significantly reduces the incidence of pancreatic infection^[3].

383.46

C₁₇H₂₅N₃O₅S

96036-03-2

美罗培南；美洛培南

• Antibiotics
• Beta-lactam Antibiotics

aerobes and anaerobes

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.