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FGIN-1-27
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
FGIN-1-27图片
CAS NO:142720-24-9
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
FGIN-1-27 是一种吲哚乙酰胺，是一种特异性的外周苯二氮卓受体 (PBR) 配体，Ki 为 5.0 nM。
Cas No.142720-24-9
别名N,N-二己基-2-(4-氟苯)吲哚-3-乙酰胺
化学名2-(2-(4-fluorophenyl)-1H-indol-3-yl)-N,N-dihexylacetamide
Canonical SMILESFC1=CC=C(C=C1)C(NC2=CC=CC=C32)=C3CC(N(CCCCCC)CCCCCC)=O
分子式C28H37FN2O
分子量436.61
溶解度30mg/mL in ethanol, 20mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

FGIN-1-27 is an indoleacetamide that acts as a high affinity agonist of the 18 kDa translocator protein (TSPO; previously called the peripheral benzodiazepine receptor) with a Ki value of 5 nM.1 It can enhance steroidogenesis of neuroactive steroids such as allopregnanolone.[1] Through this action, FGIN-1-27 indirectly potentiates GABAA receptor signaling to produce anticonvulsant, anxiolytic, and sedative activity in both animal and clinical models.[1]

Reference:
[1]. James, M.L., Selleri, S., and Kassiou, M. Development of ligands for the peripheral benzodiazepine receptor. Current Medicinal Chemistry 13(17), 1991-2001 (2006).