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8-Bromo-cGMP,sodium salt
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
8-Bromo-cGMP,sodium salt图片
CAS NO:51116-01-9
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
8-Bromo-cGMP，钠盐，一种 cGMP 的膜可渗透类似物，是一种 PKG（蛋白激酶 G）激活剂。
Cas No.51116-01-9
别名8-溴代鸟苷-3',5'-环状单磷酸酯钠盐,??8-bromo-cGMP, 8-bromo Guanosine 3’,5’-cyclic monophosphate
化学名8-bromo-guanosine cyclic 3',5'-(hydrogen phosphate), monosodium salt
Canonical SMILESBrC1=NC2=C(NC(N)=NC2=O)N1[C@@H]3O[C@@H]4[C@H]([C@H]3O)O[P@](OC4)([O-])=O.[Na+]
分子式C10H10BrN5NaO7P
分子量446.09
溶解度10mg in PBS(pH7.2)
储存条件Desiccate at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

8-bromo-Cyclic GMP (8-bromo-cGMP) is a cell-permeable analog of cGMP that exhibits greater resistance to hydrolysis by phosphodiesterases than its parent compound. It preferentially activates cGMP-dependent protein kinase.[1] At 1 μM-0.1 mM, 8-bromo-cGMP can inhibit acetylcholine-induced increases in intracellular calcium concentrations.[2]

Reference:
[1]. Rashatwar, S.S., Cornwell, T.L., and Lincoln, T.M. Effects of 8-bromo-cGMP on Ca2+ levels in vascular smooth muscle cells: Possible regulation of Ca2+-ATPase by cGMP-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America 84(16), 5685-5689 (1987).
[2]. Choi, J., and Farley, J.M. Effects of 8-bromo-cyclic GMP on membrane potential of single swine tracheal smooth muscle cells. Journal of Pharmacology and Experimental Therapeutics 285(2), 588-594 (1998).