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P1075
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
P1075图片
CAS NO:60559-98-0
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
P1075 是磺酰脲受体 2 相关的 ATP 敏感钾通道 (SUR2-KIR6) 的有效激活剂，激活 SUR2B-KIR6 通道的 EC50 值为 45 nM。
Cas No.60559-98-0
Canonical SMILESN#CN/C(NC1=CC=CN=C1)=N\C(C)(C)CC
分子式C12H17N5
分子量231.3
溶解度DMSO:<100mM,Ethanol:<50mM
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

P-1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6), with an EC50 value of 45 nM for SUR2B-KIR6 channel activation[1]. P-1075 also P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts[2].

References:
[1]. Schwanstecher M, et al. Potassium channel openers require ATP to bind to and act through sulfonylurea receptors. EMBO J. 1998 Oct 1;17(19):5529-35.
[2]. Oldenburg O, et al. P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts. J Mol Cell Cardiol. 2003 Sep;35(9):1035-42.