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DCEBIO
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
DCEBIO图片
CAS NO:60563-36-2
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
DCEBIO 是 1-EBIO 的衍生物，是 T84 结肠细胞中 Cl-分泌的极强激活剂 。
Cas No.60563-36-2
别名5,6-2氯-1-乙基-1H-苯并咪唑-2酮
化学名5,6-dichloro-1-ethyl-1H-benzo[d]imidazol-2(3H)-one
Canonical SMILESClC(C=C(C(NC1=O)=C2)N1CC)=C2Cl
分子式C9H8Cl2N2O
分子量231.08
溶解度<23.11mg/ml in ethanol;<23.11mg/ml in DMSO
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DCEBIO, a derivative of 1-EBIO, is an extremely potent activator of Cl－ secretion in T84 colonic cells[1]. DCEBIO stimulates Cl－ secretion via the activation of hIK1 K＋ channels and the activation of an apical membrane Cl－ conductance[2].

References:
[1]. Hamilton KL,et al. DCEBIO stimulates Cl- secretion in the mouse jejunum. Am J Physiol Cell Physiol. 2006 Jan;290(1):C152-64.
[2]. Singh S, et al. Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J Pharmacol Exp Ther. 2001 Feb;296(2):600-11.