ITKantagonist (compound 10 n) is a potent, orally active and selectiveITK(Interleukin-2 inducible T-cell kinase) antagonist (IC₅₀=1 and 20 nM in different assays).ITKantagonist inhibitsinsulin receptorkinase (IRK) with an IC₅₀of 160 nM^[1].

ITK antagonist inhibits DT40 cell (IC₅₀=4 nM) and shows IL-2 inhibition (IC₅₀=20 nM)^[1].

494.65

C₂₆H₃₄N₆O₂S

1149753-56-9

Room temperature in continental US; may vary elsewhere.

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