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tBID
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
tBID图片
CAS NO:1639895-85-4
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
tBID 是同源结构域相互作用蛋白激酶2 (HIPK2) 的选择性抑制剂,IC50值为 0.33 μM。
生物活性

tBID is a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2) with anIC50of 0.33 μM.

IC50& Target

IC50: 0.33 μM (HIPK2)[1]

体外研究
(In Vitro)

Homeodomain-interacting protein kinase 2 (HIPK2) is a Ser/Thr kinase controlling cell proliferation and survival. TBID, displays toward HIPK2 unprecedented efficacy (IC50=0.33 μM) and selectivity (Gini coefficient 0.592 out of a panel of 76 kinases). The two other members of the HIPK family, HIPK1 and HIPK3, are also inhibited by TBID albeit less efficiently than HIPK2. The mode of action of TBID is competitive with respect to ATP, consistent with modelling. TBID interacts with the hinge region through hydrophobic interactions between Val 213, Val 261, Phe 277, Leu 280, Met 331, Ile 345, and the tetrabromine moiety, while the symmetric nitrogen atom at position 3 interacts with the catalytic Lys 228, thus playing a crucial role in the binding architecture[1].

分子量

528.78

性状

Solid

Formula

C11H3Br4N3O2

CAS 号

1639895-85-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 20 mg/mL(37.82 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.8911 mL9.4557 mL18.9115 mL
5 mM0.3782 mL1.8911 mL3.7823 mL
10 mM0.1891 mL0.9456 mL1.8911 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。