CAS NO: | 1780303-76-5 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | DDR1-IN-1 dihydrochloride is a potent and selectiveDDR1receptor tyrosine kinaseinhibitor with anIC50of 105 nM; 4-fold less potent forDDR2(IC50= 413 nM)[1]. | ||
IC50& Target |
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体外研究 (In Vitro) | DDR1-IN-1 effectively blocks collagen-induced DDR1 pY513 autophosphorylation in U2OS cells (EC50= 86.76 nM) with excellent selectivity over a panel of >380 kinases. DDR1-IN-1 inhibits DDR2-mediated MT1-MMP activation in human rheumatoid synovial fibroblasts (RASF) upon collagen stimulation (IC50< 2.5 μM) and enhances PI3K/mTOR inhibitor GSK2126458 antiproliferation efficacy in SNU-1040 colorectal cancer culture[1]. | ||
分子量 | 625.51 | ||
Formula | C30H33Cl2F3N4O3 | ||
CAS 号 | 1780303-76-5 | ||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |