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DDR1-IN-1 dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DDR1-IN-1 dihydrochloride图片
CAS NO:1780303-76-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
DDR1-IN-1 dihydrochloride是DDR1受体酪氨酸激酶抑制剂,IC50值为105 nM,而对 DDR2 的 IC50为413 nM。
生物活性

DDR1-IN-1 dihydrochloride is a potent and selectiveDDR1receptor tyrosine kinaseinhibitor with anIC50of 105 nM; 4-fold less potent forDDR2(IC50= 413 nM)[1].

IC50& Target

DDR1

105 nM (IC50)

DDR2

413 nM (IC50)

体外研究
(In Vitro)

DDR1-IN-1 effectively blocks collagen-induced DDR1 pY513 autophosphorylation in U2OS cells (EC50= 86.76 nM) with excellent selectivity over a panel of >380 kinases. DDR1-IN-1 inhibits DDR2-mediated MT1-MMP activation in human rheumatoid synovial fibroblasts (RASF) upon collagen stimulation (IC50< 2.5 μM) and enhances PI3K/mTOR inhibitor GSK2126458 antiproliferation efficacy in SNU-1040 colorectal cancer culture[1].

分子量

625.51

Formula

C30H33Cl2F3N4O3

CAS 号

1780303-76-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.