CAS NO: | 1237536-18-3 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | ML786 dihydrochloride is a potent and orally bioavailableRafinhibitor, withIC50s of 2.1, 4.2, and 2.5 nM forV600EΔB-Raf,wt B-Raf, andC-Raf, respectively. ML786 dihydrochloride also inhibitsAbl-1,DDR2,EPHA2,KDR, andRET(IC50=<0.5, 7.0, 11, 6.2, 0.8 nM). ML786 dihydrochloride can be used for the research of cancers[1]. | ||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | ML786 (3 h) inhibits the kinase phosphorylation of extracellular signal-regulated kinase (ERK) (pERK) in A375 cells, with an IC50of 60 nM[1]. | ||||||||
体内研究 (In Vivo) | ML786 (75 mg/kg; p.o. once daily for 21 d) inhibits the subcutaneous A375 M xenografts in immunocompromised mice[1].
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分子量 | 611.48 | ||||||||
Formula | C29H31Cl2F3N4O3 | ||||||||
CAS 号 | 1237536-18-3 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |