CAS NO: | 417716-92-8 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
2mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibitsVEGFR1-3,FGFR1-4,PDGFR,KIT, andRET, shows potent antitumor activities[1][2]. | ||||||||||||||||
IC50& Target[1][2][3] |
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体外研究 (In Vitro) | Lenvatinib (E7080) has IC50s of 4, 5.2, 22 nM for VEGFR2 (KDR), VEGFR3 (Flt-4), and VEGFR1 (Flt-1), respectively. Lenvatinib inhibits PDGFRα, PDGFRβ, FGFR1, and KIT with IC50s of 51, 39, 46, and 100 nM, respectively[3]. | ||||||||||||||||
体内研究 (In Vivo) | Lenvatinib (E7080) (100 mg/kg, p.o.) significantly inhibits local tumor growth at the m.f.p., and at the end of treatment, Lenvatinib mesylate also significantly inhibits metastasis to both regional lymph nodes and distant lung[3]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 426.85 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C21H19ClN4O4 | ||||||||||||||||
CAS 号 | 417716-92-8 | ||||||||||||||||
中文名称 | 乐伐替尼;仑伐替尼;乐法替尼 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 12.78 mg/mL(29.94 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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