SNIPER(TACC3)-11

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SNIPER(TACC3)-11

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

SNIPER(TACC3)-11 是一种有效的成纤维细胞生长因子受体 3 转化酸性卷曲螺旋蛋白 3 (FGFR3-TACC3)抑制剂。SNIPER(TACC3)-11 降低 FGFR3-TACC3 蛋白水平，抑制 FGFR3-TACC3 阳性癌细胞的生长。

生物活性

SNIPER(TACC3)-11 is a potentFGFR3-TACC3degrader. SNIPER(TACC3)-11 reduces FGFR3-TACC3 protein levels and suppressed the growth of FGFR3-TACC3 positivecancercells^[1].

IC₅₀& Target

FGFR3-TACC3^[1]

体外研究
(In Vitro)

SNIPER(TACC3)-11 (compound 5a) (0.3-3 μM; 6 hours) reduces FGFR3-TACC3 levels^[1].
SNIPER(TACC3)-11 (0.3-3 μM; 72 hours) inhibits the growth of RT4 cells at 3 μM, and does not inhibit the growth of HeLa cells^[1].

Western Blot Analysis

Cell Line:	RT4 cells^[1]
Concentration:	0.3, 1 and 3 μM
Incubation Time:	6 hours
Result:	Reduced FGFR3-TACC3 levels.

Cell Proliferation Assay

Cell Line:	RT4 and HeLa cells^[1]
Concentration:	0.3, 1 and 3 μM
Incubation Time:	72 hours
Result:	Dramatically inhibited the growth of RT4 cells at 3 μM, and did not inhibit the growth of HeLa cells, which indicated that SNIPER(TACC3)-11 just inhibited the proliferation of cells expressing FGFR3-TACC3.

分子量

995.26

Formula

C₅₁H₆₆N₁₀O₇S₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.