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Terbutaline
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Terbutaline图片
CAS NO:23031-25-6
包装与价格：
包装价格(元)
25mg电议
50mg电议
100mg电议
500mg电议

产品介绍
特布他林是一种口服活性β2-肾上腺素能受体激动剂，也是班布特罗的活性代谢物。
Cas No.23031-25-6
别名特布他林
化学名5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-1,3-benzenediol
Canonical SMILESOC1=CC(O)=CC(C(O)CNC(C)(C)C)=C1
分子式C12H19NO3
分子量225.3
溶解度DMSO: slightly soluble,Methanol: slightly soluble,Water: 100 mM
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Terbutaline is a short-acting β2-adrenergic receptor (β2-AR) agonist and an active metabolite of bambuterol .[1],[2],[3] It binds to β1-, β2-, and β3-ARs (Ki = 31.3, 15.4, and 79.8 nM, respectively) and selectively increases adenylyl cyclase activity in CHO cell membranes expressing recombinant human β2- or β3- over β1-ARs at concentrations 100-fold greater than the respective Ki values.[1] Terbutaline inhibits histamine release induced by ovalbumin in isolated guinea pig lung mast cells.[2] It also inhibits airway obstruction induced by methacholine or leukotriene D4 in anesthetized guinea pigs.[4] Formulations containing terbutaline have been used in the treatment of asthma.

Reference:
[1]. Hoffmann, C., Leitz, M.R., Oberdorf-Maass, S., et al. Comparative pharmacology of human β-adrenergic receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch. Pharmacol. 369(2), 151-159 (2004).
[2]. Lau, H.Y.A., Wong, P.L., and Lai, C.K.W. Effects of β2-adrenergic agonists on isolated guinea pig lung mast cells. Agents Actions 42(3-4), 92-94 (1994).
[3]. Olsson, O.A.T., and Svenson, L.-o. New lipophilic terbutaline ester prodrugs with long effect duration. Pharm. Res. 1(1), 19-23 (1984).
[4]. Salonen, R.O. Actions of bronchodilator drugs, glucocorticoid, and their combinations on airways in rats and guinea pigs. Acta. Pharmacol. Toxicol. (Copenh) 57(Suppl. 3), 1-38 (1985).